论文部分内容阅读
ＴＧＦβ１调节细胞增殖、分化、免疫反应以及刺激细胞外基质增生。ＴＧＦβ１在肾小球纤维化病理生理机制中发挥重要作用，从基因水平阻断ＴＧＦβ１表达进而防治肾纤维化是目前研究的重要课题。本文综述肾脏ＴＧＦβ１促纤维化作用、ＨＶＪ－脂质体特性及其介导基因转移治疗研究进展
TGFβ1 regulates cell proliferation, differentiation, immune responses and stimulates extracellular matrix proliferation. TGFβ1 plays an important role in the pathophysiological mechanism of glomerular fibrosis. Blocking TGFβ1 expression from gene level and preventing and treating renal fibrosis is an important issue in current research. This review summarizes the role of renal TGFβ1 in promoting fibrosis, the properties of HVJ-liposomes and the progress in the treatment of gene transfer