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无协同刺激信号存在可导致Ｔ细胞产生不应答。研究证明 ,化学处理的ＡＰＣ呈递的肽抗原刺激可诱导ＣＤ4+ Ｔ细胞产生不应答 ,不应答Ｔ细胞对经ＴＣＲ识别的正常抗原刺激无反应 ,但对ＩＬ 2保持正常的反应 ;抗ＴＣＲ/ＣＤ3复合物抗体或超抗原也可诱导Ｔ细胞产生不应答 ;抗ＩＬ 2
The absence of a co-stimulatory signal can cause T cells to produce an unresponsiveness. Studies have demonstrated that stimulation of peptide antigens presented by chemically-treated APCs induces an unresponsiveness of CD4 + T cells that do not respond to normal antigen stimulation recognized by TCR but maintain normal responses to IL2; anti-TCR / CD3 complexes Antibodies or superantigens can also induce T cells to produce unresponsiveness; anti-IL2