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目的:探讨适形调强放射治疗(intensity modulated radiation therapy,IMRT)联合同步化疗在鼻咽癌(nasopharyngeal carcinoma,NPC)中的近期疗效。方法:我院2012年6月—2013年2月行IMRT联合同步化疗4例NPC患者,4例均采用9野共面IMRT,应用Eclipse 8.9治疗计划系统行逆向计划,处方剂量肿瘤区(PGTV)(66~70)Gy分(30~33)次,高危预防区(PTV1)60Gy(33次),低危预防区(PTV2)50Gy(28次),联合同步单药顺铂化疗,30mg/m2,每周1次。结果:放化疗结束后行全面检查3例疗效评价为完全缓解(CR),1例部分缓解(PR)。所有患者治疗期间未出现严重放化疗副反应,均能完成预定治疗方案,2例随访满3个月患者口干反应已基本恢复,皮肤、黏膜反应消失。结论:鼻咽癌患者采用IMRT联合同步化疗可获得较好近期疗效,不良反应可耐受,患者治疗后的生存质量得到改善。
Objective: To investigate the short-term effect of intensity modulated radiation therapy (IMRT) combined with concurrent chemotherapy in nasopharyngeal carcinoma (NPC). Methods: Four patients with NPC were treated with IMRT combined with concurrent chemotherapy in our hospital from June 2012 to February 2013. Nine patients were treated with 9-field co-planar IMRT. The patients were treated with Eclipse 8.9 treatment planning system reverse planning, prescription dose tumor area (PGTV) (30 ~ 33) for 66 ~ 70 Gy, 60 Gy for 33 high risk area (PTV1), 50 Gy for low risk area (PTV2), 30 mg / m2 for cisplatin , Once a week. Results: After the end of chemoradiotherapy, three cases of complete examination were evaluated as complete remission (CR) and partial remission (PR). All patients did not appear during the treatment of serious side effects of radiotherapy and chemotherapy, are able to complete the scheduled treatment, 2 patients were followed up for 3 months, patients with dry mouth response has been basically restored, skin, mucosa reaction disappeared. Conclusion: IMRT combined with concurrent chemotherapy in patients with nasopharyngeal carcinoma can achieve better short-term curative effect, and adverse reactions can be tolerated. The quality of life of the patients after treatment is improved.