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我们采用大鼠长期吸入高浓度ＳＯ2 气体的方法建立大鼠慢性阻塞性肺疾病 (ＣＯＰＤ)模型 ,目的在于观察ＣＯＰＤ大鼠吸入溴化异丙托品后气道形态学变化 ,从病理学角度来评价吸入溴化异丙托品的临床疗效。1 材料与方法1.1 实验动物Ｗｉｓｔａｒ♂大鼠 4 7只 ,体重 (99.0 6± 1
We established a rat model of chronic obstructive pulmonary disease (COPD) by long-term inhalation of high concentrations of SO2 gas in rats in order to observe the airway morphological changes after inhalation of ipratropium bromide in COPD rats. From the perspective of pathology Evaluate the clinical efficacy of inhaled ipratropium bromide. 1 Materials and methods 1.1 Experimental animals Wistar male rats 47, weight (99.0 6 ± 1