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目的:研究急性脑梗死患者在图片命名任务中脑磁图(MEG)的特征。方法:对13例单侧急性脑梗死表现出运动性失语症状的患者于发病后1～2周进行图片命名测试,同时用MEG记录了在此过程中大脑皮层相应功能区产生反应的潜伏期和磁场强度。结果:在图片命名任务中,有以下脑区域被激活:双侧枕叶、双侧颞枕叶交界区、优势半球Wernicke区、优势半球Broca区等脑区域。患者组出现:(1)优势半球Wernicke区反应ECD强度nAm与对照组nAm相比明显降低(P<0.05);(2)优势半球Broca区反应ECD强度降低;而潜伏期与对照组ms相比明显延迟。结论:MEG可灵敏的检测出急性脑梗死患者由于语言形成中枢相关皮质区域神经元及皮质下纤维的损伤而导致的优势半球Wernicke区和Broca区反应潜伏期和ECD强度发生的改变,并能客观的评价该中枢功能的损伤程度。
Objective: To study the characteristics of magnetoencephalography (MEG) in patients with acute cerebral infarction during the picture naming task. Methods: Thirteen patients with motor aphasia who developed motor aphasia in 13 patients with unilateral acute cerebral infarction were examined by image naming system 1 ~ 2 weeks after the onset of symptoms. MEG was used to record the incubation period and magnetic field of corresponding functional areas in the cerebral cortex strength. Results: In the picture naming task, the following brain regions were activated: the bilateral occipital lobe, bilateral temporal occipital lobe junction, the dominant hemisphere Wernicke region, the dominant hemisphere Broca region and other brain regions. (2) The ECD intensity of BrdU in the dominant hemisphere was decreased, while the latency of the ECD in the predominant hemisphere Wernicke was significantly lower than that of the control (nAm) (P <0.05) delay. CONCLUSIONS: MEG can sensitively detect changes in response latency and ECD intensity in Wernicke and Broca regions of predominant hemispheres caused by the formation of CNS-related cortical neurons and subcortical fibers in patients with acute cerebral infarction and can objectively Evaluate the degree of impairment of this central function.