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作为第一个进入临床应用的β-肾上腺素能阻断剂——心得安,除用于心血管疾病的治疗外,还应用于青光眼、偏头痛以至催产、流行性出血热等多种疾病。随着应用范围的不断扩大,且又常与其它药物并用,致使相互作用日益增多,有的甚至引起严重后果。脂溶性心得安口服后吸收迅速、完全。它主要在肝脏代谢,其产物是葡萄糖苷酸结
As the first β-adrenergic blocking agent to enter clinical application - propranolol, in addition to the treatment of cardiovascular disease, but also used in glaucoma, migraine and even oxytocin, epidemic hemorrhagic fever and other diseases. With the continuous expansion of the scope of application, and often with other drugs and use, resulting in an increasing interaction, and some even cause serious consequences. After the fat-soluble propranolol oral absorption quickly and completely. It is mainly metabolized in the liver, its product is glucuronidase