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高浓度蒽林短疗程治疗银屑病,可减少对正常皮肤的刺激,常用的基质为白凡士林、Lassar糊膏.蒽林在水相混溶性基质内可较迅速和完全除去,但在这类基质内的稳定性尚不清楚.作者用高效液相色谱法测定Lassar糊膏、白凡士林及Merck软膏内蒽林及其分解产物(蒽林二聚物、1,8-二羟基蒽醌)以测定蒽林在不同制剂内的稳定性及蒽林分解10%时在不同制剂内的有效期.一、在不含水杨酸的Lassar糊膏即锌糊膏内,配制0.2%蒽林制剂于24小时后测定,蒽林成分占51.2%,蒽林二聚物占41.7%,1,8-二羟基蒽醌占3.7%,这种制剂的有效期为1～2小时.但在Lassar糊膏内,蒽林初浓度为2%时,有效期为13个月;1%时,有效期为10个月;0.25%时,有效期为3个月;0.1%时,有效期为1.5个月.
High concentrations of anthralin short course of treatment of psoriasis, can reduce the stimulation of normal skin, the commonly used matrix white petrolatum, Lassar paste anthralin forest in the water-miscible matrix can be more quickly and completely removed, but in this category The stability of the matrix is not clear.Using high performance liquid chromatography to determine Lassar paste, white petrolatum and Merck ointment anthralin and its decomposition products (anthralin dimer, 1,8-dihydroxyanthraquinone) to The stability of anthralin in different formulations and the expiration date in different formulations when anthralin was decomposed by 10% were determined.Firstly, 0.2% anthralin solution was formulated in Lassar paste without salicylic acid, namely zinc paste, for 24 hours After determination, anthracene forest components accounted for 51.2%, anthracene Lin dimer accounted for 41.7%, 1,8-dihydroxyanthraquinone accounted for 3.7%, this formulation is valid for 1 to 2 hours, but in the Lassar paste, anthracene At the beginning of 2%, the effective period is 13 months; at 1%, the effective period is 10 months; at 0.25%, the effective period is 3 months; at 0.1%, the effective period is 1.5 months.