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目的评价口服胺碘酮在阵发性心房颤动发作时转为窦性心律及小剂量维持窦性心律的有效性和安全性。方法对38例阵发性心房颤动患者给予口服胺碘酮600mg/d,连用6d,以后改为400mg×6d→200mg×6d→100mg×6d→50mg×6d维持。结果26例患者在用药负荷量期间转复,12例在服药9~12d内转复,未见明显不良反应发生。结论口服小剂量胺碘酮治疗阵发性心房颤动不失为一种安全有效的药物。
Objective To evaluate the effectiveness and safety of oral amiodarone in the conversion of sinus rhythm to episodes of paroxysmal atrial fibrillation and maintenance of sinus rhythm at low doses. Methods 38 patients with paroxysmal atrial fibrillation were given oral amiodarone 600mg / d, once every 6d, then changed to 400mg × 6d → 200mg × 6d → 100mg × 6d → 50mg × 6d. Results 26 patients in the medication load during the transfer, 12 cases of medication within 9 ~ 12d, no obvious adverse reactions. Conclusion Oral small dose of amiodarone in the treatment of paroxysmal atrial fibrillation after all, is a safe and effective drug.