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本文报道以~(60)Coγ射线全身分次照射小鼠,每周一次,每次照射剂量1.70Gy,共四次,累积剂量6.80Gy,于照后3、4、5、6月观察小鼠骨髓细胞染色体的变化。结果可见,在照后3—6月小鼠骨髓亚二倍体细胞的发生率为10.7—17.7%,对照组为4.5%。受照后染色体畸变发生率最高的是相互易位,为4.0—22.7%,对照组为0.2%。G 显带分析结果证明,受照的11只小鼠中有6只具有特定染色体变化的异常克隆。实验结果提示,在辐射诱发的染色体畸变与肿瘤发生之间可能存在某种关系。
This article reports the whole body irradiation with ~ (60) Coγ-ray irradiation mice, once a week, each dose of 1.70Gy, a total of four times, the cumulative dose of 6.80Gy, after 3, 4, 5, 6 months after the mice were observed Chromosome changes in bone marrow cells. The results showed that the incidence of sub-diploid cells in bone marrow from 10 months to 6 months after irradiation was 10.7-17.7% in the control group and 4.5% in the control group. The highest incidence of chromosomal aberrations after irradiation was reciprocal translocation of 4.0-22.7% in the control group was 0.2%. G-banding analysis demonstrated that 6 out of 11 irradiated mice had abnormal clones with specific chromosomal changes. The results suggest that there may be a relationship between radiation-induced chromosomal aberrations and tumorigenesis.