糖皮质激素(GC)在急性呼吸窘迫综合征(ARDS)和脓毒症中的应用是危重症领域的研究热点。近年来,一系列基础和临床研究为GC在ARDS和脓毒症的应用提供了新的理论依据,即外周GC抵抗和“功能或相对性”肾上腺皮质功能不全。且越来越多的研究提示小剂量、长疗程GC对上述患者有益,但仍 The application of glucocorticoid (GC) in acute respiratory distress syndrome (ARDS) and sepsis is a hot topic in the field of critical care. In recent years, a series of basic and clinical studies have provided a new theoretical basis for GC application in ARDS and sepsis, that is, peripheral GC resistance and “functional or relative” adrenal insufficiency. And more and more researches suggest that low-dose and long-course GC may benefit these patients