抗苗勒氏管激素(AMH)由卵巢颗粒细胞分泌,,在卵泡生长发育中发挥负性调节作用。AMH在多囊卵巢综合征(PCOS)患者中异常升高,可能参与介导了PCOS的发病机制。本文综述了AMH的生物学特征,PCOS患者的AMH分泌水平与AMH基因表达,以及AMH信号转导通路的调节。 Anti-Mullerian hormone (AMH) is secreted by ovarian granulosa cells and plays a negative regulatory role in follicular growth and development. AMH in patients with polycystic ovary syndrome (PCOS) abnormally elevated, may be involved in the pathogenesis of PCOS. This article reviews the biological characteristics of AMH, the AMH secretion level and AMH gene expression in PCOS patients, and the regulation of AMH signal transduction pathway.