法莫替丁(Famotidine)是一个新型强效竞争性H_2受体拮抗剂。动物实验中其抗分泌效力比西米替丁强30～100倍,比雷尼替丁强6～10倍。对人胃酸过多性消化道疾病有效。抗胃酸分泌作用:口服本品5～40mg后,胃酸分泌减少程度与剂量有关,40mg时效应最强。1～3小时达峰效应,维持10～12小时。静脉注射效果比口服强1倍,这与本品生物利用度平均45％相符。持续静脉点滴达稳态血浆浓度90ng/ml后,能完全抑制 Famotidine is a new and potent competitive H 2 receptor antagonist. Anti-secretory potency in animal experiments than cimetidine 30 to 100 times stronger than ranitidine 6 to 10 times. Acid hyperactivity digestive tract disease effective. Anti-gastric acid secretion: After oral administration of 5 ~ 40mg, the degree of gastric acid secretion and dose reduction, 40mg when the strongest effect. Peak effect of 1 to 3 hours, maintaining 10 to 12 hours. Intravenous injection is 1 times stronger than oral, which is consistent with the bioavailability of 45% on average. Continuous intravenous infusion of steady-state plasma concentration of 90ng / ml, completely inhibited