0引言人乳头状瘤病毒(humanpapillomavirus,HPVs)与人体多种肿瘤有关,如宫颈癌、喉癌、口腔癌、扁桃体癌等,人乳头状瘤病毒感染是上述癌的病因之一[15]。近20年来,随着分子生物学和分子病毒学技术的不断发展,大量研究发现HPV16、18型等高危型HPV与喉癌的发生和发展密切相关[24] 0 Introduction Human papillomavirus (HPVs) is associated with a variety of human tumors, such as cervical cancer, laryngeal cancer, oral cancer, tonsillar cancer, etc. Human papillomavirus (HPV) infection is one of the causes of cancer [15]. In recent 20 years, with the continuous development of molecular biology and molecular virology, a large number of studies have found that high-risk HPV types HPV16 and HPV are closely related to the occurrence and development of laryngeal cancer [24]