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目的探讨体外有效净化骨髓中残存肿瘤细胞的方法，减少恶性淋巴瘤的复发。方法用体外液体培养联合低分子天然抑瘤物净化骨髓移植物后作自体骨髓移植（ＡＢＭＴ）治疗１１例中高度晚期恶性淋巴瘤。结果移植后均造血重建，白细胞恢复至≥１．０×１０９／Ｌ和血小板恢复至≥２０×１０９／Ｌ的平均时间分别为１４．８（１１～２２）ｄ和１５．５（１２～２３）ｄ。９例持续缓解（ＣＣＲ），中位ＣＣＲ时间４１（１２～７２）个月。１例ＡＢＭＴ４个月后复发。１例ＡＢＭＴ后达到部分缓解并于１７个月死于复发。结论认为该法治疗晚期淋巴瘤能获得造血重建并取得满意疗效。
Objective To investigate the effective method of purifying residual tumor cells in bone marrow in vitro and reduce the recurrence of malignant lymphoma. Methods The bone marrow grafts were purified by in vitro liquid culture combined with low-molecular natural anti-tumor agents and treated with autologous bone marrow transplantation (ABMT) in 11 patients with advanced-stage malignant lymphoma. Results Hematopoietic reconstitution was performed after transplantation. The average time for leukocyte recovery to ≥1.0×109/L and platelet recovery to ≥20×109/L was 14.8 (11 to 22) days and 15.5 (12 to 23, respectively). )d. Nine patients had sustained remission (CCR) with a median CCR of 41 (12-72) months. One case of ABMT recurred after 4 months. One patient achieved partial remission after ABMT and died of relapse at 17 months. The conclusion is that this method can achieve hematopoietic reconstruction and achieve satisfactory results in the treatment of advanced lymphoma.