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目的探讨小剂量奥美拉唑联合帕罗西汀治疗功能性消化不良的临床疗效。方法回顾性分析江西省广丰区人民医院2015年12月—2016年12月收治的功能性消化不良患者92例,根据治疗方法的不同分为对照组与研究组,各46例。对照组患者采用小剂量奥美拉唑治疗,研究组患者在对照组基础上加用帕罗西汀治疗,两组患者均持续治疗4周。比较两组患者的临床疗效、治疗前后症状积分,并观察患者不良反应发生情况。结果研究组患者治疗总有效率高于对照组(P<0.05)。治疗前,两组患者各症状积分比较,差异无统计学意义(P>0.05);治疗后,研究组患者各症状积分低于对照组(P<0.05)。研究组患者不良反应发生率低于对照组(P<0.05)。结论采用小剂量奥美拉唑联合帕罗西汀治疗功能性消化不良的临床疗效确切,可有效改善患者的临床症状,且安全性高。
Objective To investigate the clinical efficacy of low-dose omeprazole combined with paroxetine in the treatment of functional dyspepsia. Methods Ninety-two patients with functional dyspepsia who were treated in Guangfeng District People’s Hospital of Jiangxi Province from December 2015 to December 2016 were retrospectively analyzed. According to the different treatment methods, they were divided into control group and study group, with 46 cases in each group. Patients in the control group were treated with low-dose omeprazole. Patients in the study group were treated with paroxetine on the basis of the control group, and both groups were treated for 4 weeks. The clinical efficacy, symptom scores before and after treatment were compared between two groups, and the incidence of adverse reactions was observed. Results The total effective rate of treatment in study group was higher than that in control group (P <0.05). Before treatment, there was no significant difference between the two groups in symptom scores (P> 0.05). After treatment, the score of each symptom in study group was lower than that in control group (P <0.05). The incidence of adverse reactions in study group was lower than that in control group (P <0.05). Conclusion The low-dose omeprazole combined with paroxetine treatment of functional dyspepsia clinical efficacy is exact, can effectively improve the clinical symptoms of patients, and high safety.