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目的:通过血浆纤维蛋白原(i brinogen,FIB)浓度与非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)肿瘤负荷、远处转移及预后的相关性分析,探讨血浆FIB浓度测定在NHL患者中的临床意义。方法:采用Clauss凝固法对124例初治NHL患者作血浆FIB的定量分析。结果:NHL患者的中位血浆FIB浓度明显高于健康人群。当受累淋巴结外器官数量≥2个或受侵淋巴结区域数≥5个或血清乳酸脱氢酶(lactate dehydrogenase,LDH)浓度≥245 U/L时,血浆FIB浓度会发生显著升高。在弥漫性大B细胞淋巴瘤患者中,血浆FIB浓度与预后风险等级呈正相关;当血浆FIB浓度≥5.0 g/L时,其2年无进展生存期有缩短的趋势。结论:当NHL发生多发远处转移时常伴有血浆FIB浓度的升高;高血浆FIB血症可能提示弥漫性大B细胞淋巴瘤患者的不良预后。
OBJECTIVE: To investigate the relationship between plasma fibrinogen (FIB) concentration and tumor burden, distant metastasis and prognosis in non-Hodgkin’s lymphoma (NHL) In the clinical significance. Methods: Quantitative analysis of plasma FIB in 124 untreated NHL patients was performed by Clauss solidification. Results: The median FIB concentration of NHL patients was significantly higher than that of healthy people. When the number of extranodal lymph nodes is more than 2 or the number of affected lymph nodes is more than 5 or the concentration of serum lactate dehydrogenase (LDH) is more than 245 U / L, plasma FIB concentration will be significantly increased. In patients with diffuse large B-cell lymphoma, the plasma FIB concentration was positively correlated with the level of prognosis risk; when the plasma FIB concentration ≥ 5.0 g / L, its 2-year progression-free survival tended to shorten. CONCLUSIONS: Frequent hyperplasia of NHL is associated with elevated plasma FIB concentrations. High plasma FIB hyperlipidemia may indicate poor prognosis in patients with diffuse large B-cell lymphoma.