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维生素B族类药对于维持机体神经组织的正常代谢和功能具有重要的作用,故称之为神经营养性药物。长期以来,这类药物在临床上被广泛用于药物性耳中毒的防治,但其结果并不令人满意,不少人已对其疗效产生了怀疑。迄今为止,上述药对耳中毒防治效果的验证性研究极少,本实验初步探讨了这一问题。1 材料和方法 从SD大鼠群中选2炽耳廓反射(Preyer’sreflex,PR)灵敏且重复性好的大鼠,年龄60～70d,随机分3组,每组8只。①对照组:腹膜下注射硫酸
Vitamin B family of drugs for maintaining the normal metabolism and function of the body’s nervous tissue has an important role, it is called neurotrophic drugs. For a long time, these drugs are widely used in the clinical prevention and treatment of drug-induced ototoxicity, but the results are not satisfactory, many people have been doubts about the efficacy of its. So far, the verification of the efficacy of these drugs on the prevention and treatment of ototoxicity very few, this experiment preliminary study of this issue. MATERIAL AND METHODS One hundred and twenty-two SD rats were randomly divided into three groups (n = 8 each). The rats were aged from 60 days to 70 days. ① control group: peritoneal injection of sulfuric acid