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各种原因引起的慢性肾脏疾病进展为终末期肾衰（ｅｎｄｓｔａｇｅｒｅｎａｌｆａｉｌｕｒｅ，ＥＳＲＦ）的实质是肾脏纤维化和硬化，从而导致有效肾单位丧失和肾功能的进行性下降。近年研究揭示，炎症细胞浸润，肾脏固有细胞在致纤维化性生长因子（ｇｒｏｗｔｈｆａｃｔｏ...
Chronic kidney disease due to various causes The progression to end-stage renal failure (ESRF) is essentially renal fibrosis and cirrhosis, leading to a loss of effective nephrons and a progressive decline in renal function. Recent studies have revealed that infiltration of inflammatory cells, renal intrinsic cells in the fibrogenic growth factor (growthfactor ...