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我们曾用 DNA 固相膜法竞争杂交实验观察到,二乙基亚硝胺(DENA)诱发大鼠旰癌发生过程中,与 DNA 重复顺序互补的大鼠肝核RNA 的核苷酸顺序,在给 DENA 2周时部分有丢失;给 DENA 4周后又恢复与正常肝的相似;给 DENA 8周后又复有丢失,而且不
We have used DNA solid-phase membrane hybridization to observe the nucleotide sequence of rat liver RNA that is complementary to the sequence of DNA repeats in diethyl carnitine (DENA)-induced rat carcinogenesis. Partial loss to DENA at 2 weeks; Similar recovery to normal liver after 4 weeks for DENA; Repeated loss to DENA after 8 weeks, and no