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本文研究了头孢曲松加甲硝隆对包括腹腔感染在内的病原体的活性.12名健康志愿者每24h于30min内同时静脉输注甲硝唑lg和头孢曲松Lg(钠盐),共用3天.在用药前和最后一次输注后的12、16、20、22和24h收集各次血清作本,测定每一样本的血清杀菌效价(SBTs).采用高效液相色谱法测定两药的血清浓度,并在所有志愿者中计算出两药各自的清除率和半衰期.通过微量稀释法测定每一种药物对每一细菌(包括大肠杆菌、奇异变形杆菌、肺炎克雷伯菌、脆弱类杆菌)的2株菌的MICs.
In this paper, the activity of ceftriaxone plus metronidazole on pathogens including intra-abdominal infection was studied.All 12 healthy volunteers were given intravenous infusion of metronidazole lg and ceftriaxone Lg (sodium salt) 3 days.Serum disinfection titers (SBTs) of each sample were measured before and 12, 16, 20, 22 and 24 h after the last infusion.Using high performance liquid chromatography Drug serum concentrations were calculated and the clearance and half-life of both drugs were calculated in all volunteers.The effect of each drug on each bacterium (including E. coli, Proteus mirabilis, Klebsiella pneumoniae, Bacteroides fragilis) two strains of MICs.