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双膦酸盐是一类人工合成化合物,它在体内主要集积在活性骨的表面,与羟基磷灰石有强的结合作用,在体内和体外均显示出强的抑制骨吸收作用。最近几年这类药物临床上已用于骨质疏松症的治疗。随着我国人口老化,骨质疏松症的预防和治疗已成为当今社会老年医疗保健的一个非常重要的课题。已证实双膦酸盐可用于防治各种原因引起的骨质疏松症及各种肿瘤相关的骨病变。此类药物在国内外的研究发展迅速,目前我国临床上也广泛使用,在此简述双膦酸盐的临床应用。
Bisphosphonates are a class of synthetic compounds that accumulate mainly on the surface of active bone in vivo and have a strong binding effect with hydroxyapatite and show strong inhibition of bone resorption both in vivo and in vitro. In recent years, these drugs have been clinically used for the treatment of osteoporosis. With the population aging in our country, the prevention and treatment of osteoporosis has become a very important issue for the aged care in our society. Bisphosphonates have been shown to be useful in the prevention and treatment of various causes of osteoporosis and various tumor-associated bone lesions. The rapid development of such drugs at home and abroad, the current clinical use of our country is also widely used in this brief bisphosphonate clinical application.