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目的 :研究贯叶连翘提取物对小鼠的抗抑郁作用。方法 :选取了强迫小鼠游泳实验、小鼠尾悬吊应激实验、拮抗利血平所致的抑郁症状等实验指标。结果 :贯叶连翘提取物 15 0mg/kg、3 0 0mg/kg能显著缩短强迫游泳小鼠及尾悬吊小鼠的不动时间 ;显著拮抗利血平所致的体温下降作用和小鼠眼睑下垂作用。结论 :贯叶连翘提取物具有一定的抗抑郁作用。
Objective: To study the antidepressant effect of Hypericum perforatum on mice. Methods: Experimental indicators such as forced mouse swimming experiment, mouse tail suspension stress test, and depressive symptoms caused by antagonistic reserpine were selected. RESULTS: Hypericum perforatum L. extracts 150 mg/kg and 300 mg/kg significantly shortened the immobility time of forced swimming mice and tail-suspended mice; significantly antagonized the effects of reserpine-induced temperature drop and mouse eyelid sagging. effect. Conclusion: Hypericum perforatum extract has antidepressant effect.