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对56例2型糖尿病(T2DM)病人进行为期2周的胰岛素泵强化治疗,分析比较治疗前后的空腹血糖(FPG)及餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、胰岛素敏感指数(ISI)、空腹胰岛素(FINS)与空腹血糖(FPG)的比值。结果:胰岛素泵强化治疗后FPG、2hPG、HbAlc均较治疗前明显下降(P<0.01):FINS与FPG比值、HOMA-βI、SI均较治疗前明显升高(P<0.01)HOMA-IR较治疗前明显下降(P<0.01)。结论:利用胰岛素泵对糖尿病进行强化治疗可以显著改善T2DM患者胰岛β细胞功能,具有胰岛素用量少、低血糖发病率低、控制血糖效果显著以及治疗时间短等特点,是治疗糖尿病最有效的方法之一。
Fifty-six patients with type 2 diabetes mellitus (T2DM) underwent two weeks of intensive insulin pump treatment. The levels of fasting plasma glucose (FPG), postprandial 2h glucose, hemoglobin A1c (FINS), fasting insulin (FINS) , Body mass index (BMI), insulin resistance index (HOMA-IR), insulin secretion index (HOMA-β), insulin sensitivity index (ISI), fasting insulin (FINS) and fasting blood glucose (FPG) Results: The levels of FPG, 2hPG and HbAlc were significantly decreased after insulin pump treatment (P <0.01). The ratio of FINS and FPG, HOMA-βI and SI were significantly higher than those before treatment (P <0.01) Before treatment decreased significantly (P <0.01). Conclusion: Intensive treatment of diabetes with insulin pump can significantly improve pancreatic β-cell function in T2DM patients with the features of less insulin dosage, low incidence of hypoglycemia, significant effect of controlling blood sugar and short treatment time, which is the most effective method for the treatment of diabetes one.