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目的:正交试验法优选舒经软胶囊的提取工艺。方法:采用L9(34)正交试验,以挥发油的提取量为指标,优选挥发油提取工艺参数;采用L16(45)正交试验,以芍药苷的总量及岀膏率为指标,优选最佳醇提取工艺参数。结果:挥发油的最佳提取工艺为采用药材粗粉,加16倍量水提取5 h;醇提取的最佳工艺为每次加入10倍量70%的乙醇回流提取2次,每次1.5 h。结论:工艺参数合理,质量稳定,为舒经软胶囊的提取工艺的参数确定提供了实验依据。
OBJECTIVE: To optimize the extraction process of soft capsules by orthogonal test. Methods: L9 (34) orthogonal test was used to extract the volatile oil as the index, and the extraction process parameters of volatile oil were optimized. The optimum dosage of paeoniflorin Alcohol extraction process parameters. Results: The optimum extraction process of volatile oil was using crude meal of medicinal herbs and extracting with 16 times amount of water for 5 h. The best extraction technology of alcohol was extracting twice with 10 times of 70% ethanol refluxing for 1.5 h each time. Conclusion: The process parameters are reasonable and the quality is stable, which provides an experimental basis for the determination of the parameters of Shujing soft capsule extraction process.