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目的:探讨龙心素对血脂水平和颈动脉粥样硬化斑块的影响。方法:156例颈动脉斑块和血脂异常的患者,随机分为治疗组和对照组,治疗组78例,给予龙心素和阿司匹林治疗6个月,对照组78例仅口服阿司匹林。治疗前后进行颈动脉超声检查C-反应蛋白(CRP)、纤维蛋白原(FIB)、D-二聚体、血脂等变化情况。结果:治疗后,治疗组颈动脉内膜—中层厚度、平均斑块数、斑块面积、CRP、FIB、D-二聚体较治疗前降低,差异有显著性(P<0.05或P<0.01),并且低于对照组治疗后(P<0.05),未发现严重不良反应。结论:龙心素有稳定动脉粥样硬化及减小斑块的作用,还能调控血脂,并且安全性好。
Objective: To investigate the effect of dragon’s heart hormone on serum lipids and carotid atherosclerotic plaque. Methods: A total of 156 patients with carotid artery plaque and dyslipidemia were randomly divided into treatment group and control group. 78 patients in the treatment group were treated with Longxin and aspirin for 6 months while 78 patients in the control group were given aspirin only. Before and after treatment of carotid artery ultrasound C-reactive protein (CRP), fibrinogen (FIB), D-dimer, blood lipids and other changes. Results: After treatment, carotid artery intima - media thickness, average plaque area, plaque area, CRP, FIB, D - dimer in treatment group were significantly lower than those before treatment (P <0.05 or P <0.01) ), And lower than the control group after treatment (P <0.05), no serious adverse reactions were found. Conclusion: Longxin has stable atherosclerosis and reduce the role of plaque, but also regulate blood lipids, and good safety.