【摘 要】
：
Twenty-five derivatives of glycyrrhetinic acid(GA)modified on the A-ring,at C30 and C11 positions were synthesized.Their in vitro cytotoxicity against various c
【机 构】
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Department of Pharmaceutical Engineering,Department of Pharmacognosy
【基金项目】
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the Project-sponsored by Scientific Research Foundation for Returned Overseas Chinese Scholars,Ministry of Education of China;the Key Project of Chinese University Science Research of Liaoning Educati
论文部分内容阅读
Twenty-five derivatives of glycyrrhetinic acid(GA)modified on the A-ring,at C30 and C11 positions were synthesized.Their in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells(HeLa),human hepatocellular liver carcinoma cells(HepG2)and human gastric carcinoma cells(BGC-823)]was evaluated by standard MTT[3-(4,5-dimethyl-2-thiazol-yl)-2,5-diphenyl-2H-tetrazolium bromide]assay.All the tested derivatives were found to have stronger cell growth inhibitory than their parent compound GA.Among them,compounds 3a,5a,and 8d have similar activity on HeLa cell line,and compound 8a has similar activity on HeLa,HepG2 and BGC-823 cell lines as Gefitinib.
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