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采用十六烷基三甲基溴化铵(CTAB)作为表面活性剂修饰羧基化的单壁碳纳米管(SWNT-COOH/CTAB),并对原始单壁碳纳米管(SWNTs)与羧基化修饰的单壁碳纳米管(SWNT-COOH)进行材料学特征比较。通过细胞活力和细胞凋亡实验对SWNTs、SWNT-COOH和SWNT-COOH/CTAB的细胞毒性进行比较。结果表明,羧基化修饰的单壁碳纳米管比原始单壁碳纳米管的毒性小,单壁碳纳米管经羧基化后其毒性降低;浓度及时间曲线显示SWNT-COOH/CTAB的毒性与表面活性剂CTAB相关,CTAB和SWNT-COOH/CTAB的细胞毒性在低浓度范围内(0.5~25μg/mL)是可接受的。十六烷基三甲基溴化铵修饰的羧基化单壁碳纳米管在低浓度范围(0.5~25μg/mL)内可以较安全地用于生物医学领域。
Carboxylated single-walled carbon nanotubes (SWNT-COOH / CTAB) were modified with cetyltrimethylammonium bromide (CTAB) as surface-active agent and the primary single-walled carbon nanotubes (SWNTs) Of single-walled carbon nanotubes (SWNT-COOH) for material characterization. Cytotoxicity of SWNTs, SWNT-COOH and SWNT-COOH / CTAB was compared by cell viability and apoptosis assays. The results showed that the carboxylated modified single-walled carbon nanotubes were less toxic than the original single-walled carbon nanotubes. The toxicity of single-walled carbon nanotubes after carboxylation decreased. The concentration and time curves showed that the toxicity of SWNT-COOH / CTAB to the surface The active CTAB-related cytotoxicity of CTAB and SWNT-COOH / CTAB was acceptable at low concentrations (0.5-25 μg / mL). Cetyltrimethylammonium bromide modified carboxylated single-walled carbon nanotubes can be safely used in the biomedical field in a low concentration range (0.5-25 μg / mL).