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目的:探讨大肠癌转移与血浆可溶性CD105之间的相关性。方法:采用酶联免疫吸附试验法(ELISA)对50例大肠癌患者以及31例正常人CD105浓度进行了检测。结果:未发生转移的大肠癌患者血浆可溶性血清CD105浓度(2.42±0.46)mg/L明显高于正常对照组(1.57±0.15)mg/L(P<0.01),而低于转移性大肠癌组(4.24±0.75)(P<0.01)。结论:血浆可溶性CD105与大肠癌转移有关,有可能成为诊断其转移指标之一。
Objective: To investigate the correlation between metastasis of colorectal carcinoma and plasma soluble CD105. Methods: The concentrations of CD105 in 50 patients with colorectal cancer and 31 healthy controls were detected by enzyme linked immunosorbent assay (ELISA). Results: The serum soluble CD105 level in patients without metastasis (2.42 ± 0.46) mg / L was significantly higher than that in normal controls (1.57 ± 0.15) mg / L (P <0.01), but lower than that in metastatic colorectal cancer (4.24 ± 0.75) (P <0.01). Conclusion: Plasma soluble CD105 is associated with the metastasis of colorectal cancer and may be one of the indicators of metastasis.