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吡喹酮(praziquantel,PQT)对心肌生理特性的影响有立体选择性。(-)-PQT对离体大鼠左心房的正性肌力作用的效能和强度均比(+)-PQT和(±)-PQT小。用维拉帕米可明显减弱PQT及其对映异构体的正性肌力作用。在浓度为100μmol/1时,PQT及其对映异构体对离体大鼠右心房均有负性频率作用,而当30μmol/1时仅(+)-PQT对频率有明显影响。它们尚可诱发右心房心律失常,其发生率以(+)-PQT最高,(-)-PQT最低,(±)-PQT居中。(+)-和(±)-PQT可明显缩短左房不应期。(+)-PQT还可明显降低左房自律性,而(-)-PQT对不应期,自律性均无影响。
Praziquantel (praziquantel, PQT) on the physiological characteristics of myocardial stereoselective. (-) - PQT on isolated rat left atrium inotropic effect of potency and intensity than (+) - PQT and (±) -PQT small. Verapamil significantly attenuated the positive inotropic effect of PQT and its enantiomers. At a concentration of 100 μmol / l, PQT and its enantiomers had a negative effect on the right atrium of isolated rat hearts, while only the (+) - PQT at 30 μmol / l had a significant effect on the frequency. They can still induce right atrial arrhythmias, the incidence of (+) - PQT highest, (-) - PQT lowest, (±) -PQT center. (+) - and (±) -PQT significantly shortened the atrial refractory period. (+) - PQT also significantly reduced left atrial self-discipline, while (-) - PQT had no effect on refractory period and self-discipline.