Background:Currently,spectral-domain optical coherence tomography (SD-OCT) appears to be a new type of glaucoma diagnostic tool.Thus,this study aimed to evaluate the effectiveness of glaucoma diagnostic parameters from SD-OCT of patients with different severities of myopia.Methods:This was a cross-sectional study.A total of 248 participants (248 eyes) were enrolled,including 51 cases in the early primary open-angle glaucoma group,79 cases in the control group (0.50 D to-0.50 D,excluding-0.50 D),47 cases in the low-myopic group (-0.50 to-3.00 D,excluding-3.00 D),43 cases in the moderate-myopic group (-3.00 to-6.00 D,excluding-6.00 D),and 28 cases in the high-myopic group (≤-6.00 D).All participants were examined using the Humphrey visual field test and SD-OCT.The SD-OCT parameters of the retinal nerve fiber layer (RNFL) and ganglion cell complex were analyzed statistically using the receiver operating characteristic curve and area under the curve (AUC).Results:The AUC showed that the best parameters for the control and low-myopic groups were the inferior and inferior temporal RNFL thicknesses (AUC ＞0.94),respectively;for the moderate-and high-myopic groups,the best parameter was the temporal low RNFL thickness (AUC,0.926 and 0.896,respectively).The AUC of the inferior parameters of the moderate-myopic group (0.864) was lower,ranked 15th among all RNFL parameters.When the sensitivity was fixed at 85％,the specificity of the inferior,superior,inferior temporal,and superior temporal quadrants was higher (＞80％) in the control and low-myopic groups,while they were lower (20-60％) for the moderate-and high-myopia groups.The green color based on the OCT database was also less for the high-myopic group compared with that of other groups (P ＜ 0.05).Conclusions:Glaucoma diagnostic parameters from SD-OCT were not clinically effective for the moderate-and high-myopic groups.The specificities were low.The moderate-and high-myopic groups require comprehensive analyses for the diagnoses of glaucoma.The SD-OCT database should be improved to better indicate the level of myopia based on the corresponding diopter readings.