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目的:观察替吉奥联合奥沙利铂及多西紫杉醇治疗晚期胃癌的近期疗效,并对其用药安全性进行评估。方法:选取2010年8月—2012年8月在我院接受治疗的晚期胃癌患者68例,随机分为对照组和观察组,每组34例。对照组患者采取5-FU+奥沙利铂+多西紫杉醇进行治疗,而观察组患者给予替吉奥+奥沙利铂+多西紫杉醇进行治疗,比较两组患者接受不同药物治疗所得到的近期疗效及不良反应的发生情况。结果:观察组治疗的总有效率为58.82%,而对照组治疗的总有效率为32.35%,观察组明显高于对照组,差异显著,具有统计学意义(P<0.05);观察组患者治疗后的不良反应发生率为8.82%,而对照组患者治疗后的不良反应发生率为32.35%,观察组明显低于对照组,差异显著,具有统计学意义(P<0.05)。结论:替吉奥联合奥沙利铂及多西紫杉醇治疗晚期胃癌疗效显著,不良反应少,患者耐受良好,值得进一步推广和应用。
OBJECTIVE: To observe the short-term curative effect of tioguanide combined with oxaliplatin and docetaxel in the treatment of advanced gastric cancer and evaluate the safety of its use. Methods: Sixty-eight patients with advanced gastric cancer treated in our hospital from August 2010 to August 2012 were randomly divided into control group and observation group, 34 cases in each group. Patients in the control group were treated with 5-FU + oxaliplatin + docetaxel, while patients in the observation group were treated with tioguanxide + oxaliplatin + docetaxel. Patients in the two groups were treated with different drugs for the short term Efficacy and adverse reactions occurred. Results: The total effective rate of the observation group was 58.82%, while the total effective rate of the control group was 32.35%. The observation group was significantly higher than the control group, with significant difference (P <0.05) The incidence of adverse reactions was 8.82%, while the incidence of adverse reactions in the control group was 32.35%. The observation group was significantly lower than the control group, with significant difference (P <0.05). CONCLUSION: The effect of tioguanide combined with oxaliplatin and docetaxel in the treatment of advanced gastric cancer is significant, with few adverse reactions and well tolerated patients. It is worth further promotion and application.