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目的探讨高通量血液透析对维持性透析患者微炎症状态的影响。方法 60例维持性透析患者随机分为观察组和对照组,各30例。其中观察组给予全程高通量血液透析法治疗,对照组则给予普通血液透析治疗,治疗6个月后比较两组透析前后血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、血红蛋白(Hb)、血白蛋白(Alb)和前白蛋白(PA)水平的变化。结果透析6个月后,两组患者CRP、IL-6、IL-8及TNF-α水平较本组透析前明显下降,Hb、Alb、PA水平较本组透析前明显升高,差异均具有统计学意义(P<0.05);此外透析后观察组CRP、IL-6、IL-8及TNF-α水平[(3.23±0.98)mg/L、(148.92±22.92)ng/L、(134.54±19.21)ng/L、(311.56±40.72)ng/L]明显低于对照组[(5.06±1.12)mg/L、(269.31±41.21)ng/L、(220.45±25.76)ng/L、(442.65±60.81)ng/L],Hb、Alb、PA水平[(150.95±15.70)g/L、(39.61±1.95)g/L、(313.58±50.74)mg/L]高于对照组[(128.92±14.18)g/L、(35.72±2.92)g/L、(266.60±30.51)mg/L],差异均具有统计学意义(P<0.05)。结论高通量血液透析对维持性透析患者微炎症状态具有明显的改善作用,同时效果也优于普通血液透析,值得临床推广应用。
Objective To investigate the effect of high-flux hemodialysis on the status of micro-inflammation in maintenance hemodialysis patients. Methods Sixty patients with maintenance hemodialysis were randomly divided into observation group and control group, with 30 cases in each group. The observation group received full-scale high-throughput hemodialysis treatment, while the control group received general hemodialysis. After 6 months of treatment, the levels of serum C-reactive protein (CRP), interleukin-6 , Interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), hemoglobin (Hb), serum albumin (Alb) and prealbumin (PA) Results After 6 months of dialysis, the levels of CRP, IL-6, IL-8 and TNF-α in the two groups were significantly lower than those in the pre-dialysis group. The levels of Hb, Alb and PA in the two groups were significantly higher than those before dialysis (3.23 ± 0.98) mg / L, (148.92 ± 22.92) ng / L, (134.54 ± 0.98) ng / L, and the levels of CRP, IL-6, IL-8 and TNF- 19.21) ng / L, (311.56 ± 40.72) ng / L] were significantly lower than those in the control group [(5.06 ± 1.12) mg / L, (269.31 ± 41.21) ng / L, (220.45 ± 25.76) ng / L, L and Hb, Alb and PA levels were significantly higher than those in control group [(150.95 ± 15.70) g / L, (39.61 ± 1.95) g / L and (313.58 ± 50.74) mg / L] 14.18) g / L, (35.72 ± 2.92) g / L, (266.60 ± 30.51) mg / L], all of which were statistically significant (P <0.05). Conclusion High-throughput hemodialysis has a significant effect on the micro-inflammatory state of maintenance hemodialysis patients, and the effect is also superior to that of ordinary hemodialysis, which is worthy of clinical application.