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目的:研究DNA-PKcs蛋白表达与鼻咽癌预后的关系。方法:收集2007年5月~2012年2月经广西壮族自治区人民医院病理学确诊为鼻咽癌且选择调强放疗的患者100例。其中13例失访。采用免疫组化SP法检测87例患者中DNA-PKcs蛋白在鼻咽癌组织中的表达,分析DNA-PKcs蛋白表达与患者近期疗效、总生存以及发生远处转移之间的关系。结果:87例患者DNA-PKcs高表达60.0%,低表达40%。DNA-PKcs的表达水平与患者的近期疗效无关(P=0.348);但与患者生存时间呈正相关(r=0.234,P=0.048),单因素分析显示DNA-PKcs低表达者较高表达者更容易发生远处转移(P=0.001),而且生存时间更短(P=0.007)。结论:鼻咽癌组织中DNA-PKcs的表达水平与患者近期疗效无关,DNA-PKcs低表达可能作为预测鼻咽癌患者预后较差的一个指标。
Objective: To study the relationship between the expression of DNA-PKcs and the prognosis of nasopharyngeal carcinoma. Methods: A total of 100 patients with pathologically diagnosed nasopharyngeal carcinoma and IMRT were selected from May 2007 to February 2012 in People’s Hospital of Guangxi Zhuang Autonomous Region. Thirteen of them were lost. The expression of DNA-PKcs protein in 87 cases of nasopharyngeal carcinoma tissues was detected by immunohistochemical SP method. The relationship between the expression of DNA-PKcs protein and the short-term efficacy, overall survival and distant metastasis was analyzed. Results: The DNA-PKcs of 87 patients were highly expressed 60.0% and low-expressed 40%. The expression level of DNA-PKcs was not related to the short-term effect of the patients (P = 0.348), but positively correlated with the survival time (r = 0.234, P = 0.048). The univariate analysis showed that the higher expression of DNA- Easily distant metastasis (P = 0.001), and shorter survival time (P = 0.007). Conclusion: The expression level of DNA-PKcs in nasopharyngeal carcinoma has nothing to do with the short-term curative effect of patients. The low expression of DNA-PKcs may be used as an index to predict the prognosis of patients with nasopharyngeal carcinoma.