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大剂量化疗和/或放疗后进行骨髓移植,为在完全缓解(CR)期全部消除隐匿的白血病细胞带来了很大希望。但大多数急性粒细胞白血病(AML)患者由于无 HLA 相配的供体,或年龄过大(>45岁),致使同种骨髓移植无法进行,用自身骨髓移植(ABMT)可克服这些困难。为增加 ABMT 治疗作用,本文报道用单克隆抗体净化骨髓,对 AML 病人进行 ABMT治疗的结果。病人和方法 AML30例,年龄11～53岁。除1例由骨髓增生异常综合征转为 AML 外,其余29例开始
Bone marrow transplantation following high-dose chemotherapy and / or radiotherapy offers great promise for the complete elimination of occult leukemia cells during complete remission (CR). However, most patients with acute myeloid leukemia (AML) can not be treated with HLA-matched donors or over-age (> 45 years of age), and allogeneic BMT can be overcame with these autologous bone marrow transplantation (ABMT). In order to increase the therapeutic effect of ABMT, this paper reports the results of ABMT treatment of AML patients by using monoclonal antibody to purify bone marrow. Patients and Methods AML 30 cases, aged 11 to 53 years. In addition to one case of myelodysplastic syndrome into AML, the remaining 29 cases began