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脂质体辐射研究说明钾离子的渗漏量是照射剂量的函数,并与脂质过氧化物的生成相平行。Kocmierska Grodzka 对全身照射大鼠肝体外灌注试验观察到灌注液中钾离子含量增加,并与肝溶酶体脂质过氧化物含量升高相关。Prince等对缺乏和不缺乏维生素E(VE)小鼠的红细胞(RBC)体外辐射研究发现,前者钾离子的渗漏远较后者为明显。以上事实说明,辐射诱导的RBC钾离子渗漏与RBC膜的脂质过氧化作用有关。辐射脂质过氧化作用的特点之一是剂量率效应。最近Konings报道了辐
Liposomal radiation studies have shown that leakage of potassium ions is a function of irradiation dose and is parallel to the formation of lipid peroxides. Kocmierska Grodzka’s results showed that the extracorporeal perfusion in rat liver increased the content of potassium in perfusate and was related to the increase of hepatic lysosome lipid peroxides. Prince et al. In vitro radiotherapy of erythrocytes (RBCs) in mice lacking and lacking vitamin E (VE) revealed that the former had a much greater leakage of potassium than the latter. The above facts show that radiation-induced RBC potassium leak and RBC membrane lipid peroxidation. One of the characteristics of radiation lipid peroxidation is the dose-rate effect. Konings recently reported the spokes