用静脉注射大肠杆菌内毒素复制大鼠内毒素休克模型,动态观察血压及死亡率的变化,并分别在休克1h、3h、6h 3个时点测定心室肌组织中MDA含量及SOD活性。结果表明:休克组动物血压呈明显的3个时相变化,5min内迅速下降,30min略有回升,随后逐渐下降,至3h时,血压呈不可逆下降,与对照组相比有显著差异(P<0.05)。随血压下降,心肌MDA含量升高,至3h时与对照组相比有显著差异(P<0.05),6h时升高更加明显;与此同时,心 The model of endotoxin shock was established by intravenous injection of E. coli lipopolysaccharide and the changes of blood pressure and mortality were observed. The content of MDA and the activity of SOD in ventricular muscle were measured at 1h, 3h and 6h after shock respectively. The results showed that the blood pressure of rats in shock group showed obvious three time phase changes, decreased rapidly in 5 minutes and slightly increased in 30 minutes, then decreased gradually. The blood pressure showed an irreversible decrease at 3 hours, which was significantly different from the control group (P < 0.05). With the decrease of blood pressure, myocardial MDA content increased to 3h compared with the control group were significantly different (P <0.05), 6h elevated more significantly; at the same time, the heart