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目的研究碘染色对食管早癌和不典型增生的检出率,阐明碘染色的临床意义。方法对385名行内镜检查的食管癌高危人群进行2.5%卢戈氏碘液染色,在直径>0.5cm的不染区或淡染区内取活检,计算轻、中、重度不典型增生和早癌的检出率。结果轻度、中度和重度不典型增生/早癌的检出率分别为7.5%、2.6%和3.4%。碘染色对诊断重度不典型增生的敏感性、特异性、阳性预测值和阴性预测值分别为84.6%、92.5%、40.7%和99.0%。结论内镜下碘染色能提高食管早癌和不典型增生的检出率,是诊断食管早癌和不典型增生的一种安全、简便而有效的方法。
Objective To study the detection rate of iodine staining on early esophageal cancer and atypical hyperplasia and clarify the clinical significance of iodine staining. Methods 385 endoscopic high-risk esophageal cancer patients were subjected to 2.5% Lugol’s iodine staining, biopsies were taken in non-dyed or light-stained areas> 0.5cm in diameter to calculate the light, moderate and severe atypical hyperplasia and Early detection rate of cancer. Results The detection rates of mild, moderate and severe dysplasia / early cancer were 7.5%, 2.6% and 3.4% respectively. The sensitivity, specificity, positive predictive value and negative predictive value of iodine staining for the diagnosis of severe dysplasia were 84.6%, 92.5%, 40.7% and 99.0%, respectively. Conclusion Endoscopic iodine staining can improve the detection rate of early esophageal cancer and dysplasia, which is a safe, simple and effective method for the diagnosis of early esophageal cancer and dysplasia.