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对1990年4月至1991年10月烧伤面积≥20％的住院病人59例,进行了血浆肾素活性(PRA)、血管紧张素Ⅱ(AⅡ)及心房肽的检测,并同步检测了有关肾功能的指标,结果表明:烧伤后血浆肾素活性(PRA)、血管紧张素Ⅱ(AⅡ)、心房肽(ANP)、AⅡ/ANP均显著增加,伤后41天仍高于对照水平;伤后AⅡ增加幅度大、存在着AⅡ/ANP明显失衡,且与烧伤面积和深度、病情及肾功能损害程度密切相关。我们认为AⅡ与ANP失衡可能参与了烧伤后肾小球滤过功能、近曲小管、髓拌、远曲小管和集合管的损害。
Fifty-nine inpatients with burn area of ≥20% from April 1990 to October 1991 were tested for plasma renin activity (PRA), angiotensin Ⅱ (Ⅱ) and atrial natriuretic peptide. Simultaneously, The results showed that plasma renin activity (PRA), angiotensin Ⅱ (AⅡ), atrial natriuretic peptide (ANP), AⅡ / ANP were significantly increased after burn, but still higher than the control level after burn 41 days. A Ⅱ increased amplitude, there is a clear imbalance of A Ⅱ / ANP, and the area and depth of burn, disease and renal damage are closely related. We believe that imbalance of AⅡ and ANP may be involved in the damage of glomerular filtration function, proximal convoluted tubule, medullary tubule, distal convoluted tubule and collecting duct after burn injury.