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Aplastic anemia (AA) is a common hematopoietic function failure disease,including congenital AA and acquired AA. Congenital AA mainly due to FA-related genes mutation and acquired AA is primarily thought to result from immune dysfunction,the decline of hematopoietic stem cells and the abnormality of hematopoietic microenvironment. AA animal model plays an important role in studying AA\'s pathological mechanism and selecting effective drugs. This article summarizes the establishing methods about AA animal model in recent years\' related articles.