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原小檗碱类和四氢原小檗碱类为苄基异喹啉类生物碱的重要组成部分。它们可以由许多科植物中分得。番荔枝科(Annonaceae)、小檗科(Berberidaceae)、旋花科(Convolvulaceae)、蓝堇科(Fumariaceae)、樟科(Lauraceae)、防己科(Menispermaceae)、罂粟科(Papaveraceae)、毛茛科(Ranuculaceae)和芸香科(Rutaceae)为这类生物碱的主要来源。近十年来大量具有原小檗碱结构的化合物被分离出来,其中有些进行了药理研究。它们的主要活性为:抗微生物、降压、镇静、抗白血病和抗肿瘤。
Protoberberines and tetrahydroprotoberberines are important components of benzyl isoquinoline alkaloids. They can be divided among many families of plants. Annonaceae, Berberidaceae, Convolvulaceae, Fumariaceae, Lauraceae, Menispermaceae, Papaveraceae, Ranuculaceae ) And Rutaceae are the major sources of such alkaloids. A large number of compounds with protoberberine structure have been isolated in recent ten years, some of which have been studied pharmacologically. Their main activities are: anti-microbial, antihypertensive, sedative, anti-leukemia and anti-tumor.