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本文研究了30例呼吸道感染病人肌注妥布霉素的临床药动学,用FPIA法测定血药浓度,30例病人肌注80mg妥布霉素后的峰浓度为3.21±0.76mg/L,谷浓度为0.04±0.08mg/L:20例病人肌注2.8±0.4mg/kg妥布霉素后的峰浓度为7.44±2.10mg/L,谷浓度为0.28±0.30mg/L,Bayesian法拟合的药动学参数为,t_(1/2)2.30±0.42h,V_d 0.3341±0.0480L/kg,CL103.94±24.09ml/h·kg,观察和计算结果表明,妥布霉素肌注给药,以每次2.0～2.5mg/kg,1次/12h的给药方案较好。
In this paper, clinical pharmacokinetics of penicillin in 30 patients with respiratory tract infection were studied. The plasma concentration of FPA was measured by FPIA. The peak concentration of 30 mL intramuscular injection of tobramycin was 3.21 ± 0.76 mg / L, The trough concentration was 0.04 ± 0.08mg / L. The peak concentration of tobramycin was 7.44 ± 2.10mg / L and the trough concentration was 0.28 ± 0.30mg / L in 20 patients with intramuscular injection of 2.8 ± 0.4mg / kg. The Bayesian method The pharmacokinetic parameters were as follows: t_ (1/2) 2.30 ± 0.42h, V_d 0.3341 ± 0.0480L / kg and CL103.94 ± 24.09ml / h · kg. The results of observation and calculation showed that intramuscular injection of tobramycin Administration, to each 2.0 ~ 2.5mg / kg, 1 / 12h dosing schedule is better.