论文部分内容阅读
目的 :探讨葛根总黄酮治疗去势大鼠鼻粘膜萎缩的效果。方法 :将 6 0只成年雌性大鼠随机等分为 4组 :第 1组 :为正常对照组 ;第 2组 :行去势处理 ;第 3组 :于去势后以维尼安治疗。第 4组 :于去势后以葛根总黄酮治疗。对各组动物鼻中隔粘膜进行光镜、电镜观察 ;抽血测定血清雌二醇水平。结果 :去势后 30 d鼻粘膜呈萎缩性改变 ;经维尼安、葛根总黄酮胃灌注治疗 30 d后 ,鼻粘膜可恢复正常的形态结构。去势 30 d后动物血清雌二醇水平与正常组比较明显下降 ,差异有显著性意义 (P <0 .0 5 ) ;经维尼安治疗 ,血清雌二醇水平更趋于下降 (P <0 .0 5 ) ;经葛根总黄酮治疗后 ,血清雌二醇水平可恢复正常 (P >0 .0 5 )。结论 :葛根总黄酮可恢复去势大鼠的雌激素水平 ,对由于雌激素水平下降所致的鼻粘膜萎缩有较好的治疗作用。
Objective: To investigate the effect of Pueraria total flavone on nasal mucosa atrophy in ovariectomized rats. Methods: Sixty adult female rats were randomly divided into four groups: Group 1: normal control group; Group 2: castration treatment; Group 3: treated with Vignan after castration. Group 4: Pueraria total flavonoids after castration treatment. The mucosa of nasal septum of each group was observed by light microscope and electron microscope. The level of serum estradiol was determined by blood sampling. Results: The nasal mucosa showed atrophic changes 30 days after castration. The nasal mucosa returned to its normal morphology after 30 days of treatment with Vignan and Pueraria total flavonoids. After 30 days of castration, the level of serum estradiol significantly decreased compared with that of the normal group (P <0.05), while the serum estradiol level tended to decrease (P <0 05) .0 5). After the Pueraria total flavonoids treatment, serum estradiol levels returned to normal (P> 0.05). Conclusion: Pueraria total flavonoids can restore estrogen levels in ovariectomized rats, which has a good therapeutic effect on nasal mucosa atrophy due to the decrease of estrogen levels.