软药(Soft Drug)是在药物代谢基础上设计药物的一系有希望的新途径。软药是具有生物活性的物质,其结构类似于已知药物或是完全新颖的结构。可从化学上预测其在体内分解成无毒物质。要使药物有效,必须使其到达靶器官部位后在一段时间内维持其治疗剂量。因此,药物设计者应从生物活性的分子结构和释药系统上着手改革。初期的软药设计概念是为了防止大多数的氧化代谢作用,这是由于药物在体内各种氧化酶系的作用下,常可氧化代谢为高反应性中间 Soft Drugs are a promising new way to design drugs based on drug metabolism. Soft drugs are biologically active substances whose structure resembles known drugs or completely novel structures. It can be chemically predicted to break down in the body into non-toxic substances. For the drug to be effective, it must be maintained at a therapeutic dose for a period of time after it reaches the target organ site. Therefore, drug designers should embark on reforms from the biologically active molecular structure and drug delivery system. The initial concept of soft drug design is to prevent most of the role of oxidative metabolism, which is due to the role of drugs in the body of various oxidases, often oxidative metabolism of highly reactive intermediate