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一、重要性大多数药物是一种异物,进入体内产生生理、药理作用,来纠正机体的病理、代谢、免疫功能,达到治疗疾病的目的.大部分药物既具治疗作用,同时又有一定的副作用或毒性.常常因为个体差异,同一剂量效果悬殊,有的尚未产生药效,有的却已达中毒量.过去凭医生经验用药,容易产生差错事故.许多药物可以长效,但也有不少药物容易引起慢性中毒;有的会致癌、致畸、致突变等.为了减少盲目性,保障人民的健康,国外广泛开展药物代谢的研究.对一个新药在推广应用前都必须有药物代谢的研究结果,作为评价的重要指标之一.已经推广的药物要废除它,也需要有足够的代谢研究资料的根据.1975年世界卫生组织发表了评价药
First, the importance of most drugs is a foreign body, into the body to produce physiological and pharmacological effects, to correct the body’s pathology, metabolism, immune function, to achieve the purpose of treatment of the disease.Most drugs have both the role of treatment, while there is a certain Side effects or toxicity, often because of individual differences, the same dose effect disparity, and some have not yet produced efficacy, while others have reached the toxic dose. In the past with the doctor’s experience medication, prone to error accidents. Many drugs can be long-lasting, but there are many Drugs can easily cause chronic poisoning; Some may cause cancer, teratogenicity, Mutagenesis, etc .. In order to reduce the blindness, to protect people’s health, extensive foreign drug metabolism research .A new drug in the promotion and application must have a drug metabolism research The results, as one of the important indicators of evaluation, have been abolished to promote the drug, but also need to have sufficient basis for the study of metabolic information .1975 World Health Organization published evaluation drug