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目的评价血清脑钠肽水平对二尖瓣轻度狭窄患者心房纤颤(简称房颤)的诊断价值。方法随机选取海安人民医院2012年1月至2015年1月住院的二尖瓣轻度狭窄患者152例为研究对象,按是否确诊为房颤分为房颤组(n=22)和非房颤组(n=130),比较两组患者的基本临床特征,并以血清脑钠肽水平对房颤诊断与否分别绘制受试者工作特征(ROC)曲线。结果房颤组的年龄、左房内径、血清脑钠肽水平均高于非房颤组,差异有统计学意义(P<0.05);而两组在性别、血压、左室射血分数等方面差异均无统计学意义(P>0.05)。血清脑钠肽水平为二尖瓣轻度狭窄发生房颤的独立预测因素。血清脑钠肽水平诊断房颤的ROC曲线下面积为0.701[95%CI(0.600,0.802),P=0.003]。结论血清脑钠肽水平对二尖瓣轻度狭窄患者的房颤具有临床诊断价值,值得关注。
Objective To evaluate the diagnostic value of serum brain natriuretic peptide in patients with mild stenosis of mitral stenosis (AF). Methods We randomly selected 152 patients with mild mitral stenosis who were hospitalized from January 2012 to January 2015 in Haian People’s Hospital. According to whether they were diagnosed as atrial fibrillation, they were divided into atrial fibrillation group (n = 22) and non-atrial fibrillation (N = 130). The basic clinical characteristics of two groups of patients were compared. The receiver operating characteristic (ROC) curves of patients with atrial fibrillation were determined by serum brain natriuretic peptide levels. Results The age, atrial diameter of left atrium and serum brain natriuretic peptide in atrial fibrillation group were significantly higher than those in non-atrial fibrillation group (P <0.05). However, gender, blood pressure, left ventricular ejection fraction There was no significant difference (P> 0.05). Serum brain natriuretic peptide level was an independent predictor of atrial fibrillation in mild mitral stenosis. The area under the ROC curve of serum brain natriuretic peptide in the diagnosis of atrial fibrillation was 0.701 [95% CI (0.600, 0.802), P = 0.003]. Conclusions Serum brain natriuretic peptide has clinical value in the diagnosis of atrial fibrillation in patients with mild stenosis of mitral valve.