卵巢过度刺激综合征(OH SS)是体外受精-胚胎移植(IVF-ET)过程中的严重并发症,尽管进行了多方面的研究,但发病机理至今依然不清。目前致病因素主要集中在以下几个方面:血管内皮生长因子(VEGF)及其受体(VEGFR)、细胞因子、肾素-血管紧张素系统、基因突变等。由于这些因素的作用,导致血管通透性增加,引起相应的病理生理的改变,导致OH SS的发生。 Ovarian hyperstimulation syndrome (OH SS) is a serious complication of in vitro fertilization-embryo transfer (IVF-ET). Although various studies have been done, the pathogenesis remains unclear. Currently the main risk factors are concentrated in the following areas: vascular endothelial growth factor (VEGF) and its receptor (VEGFR), cytokines, renin - angiotensin system, gene mutations. As a result of these factors, leading to increased vascular permeability, causing the corresponding pathophysiological changes, leading to the occurrence of OH SS.