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目的:分别对儿童危重症患者血清降钙素原和C-反应蛋白水平与预后的关系进行研究,探讨两者与危重症患者预后的关系。方法:回顾性分析2011年1月~2013年6月入住哈尔滨医科大学附属第一医院新生儿重症监护病房与儿科重症监护病房的108例患者,依据其入院时血清降钙素原和C-反应蛋白水平的测定值分别进行分组,计算病死率,并且进行统计学比较。血清降钙素原水平以0.5μg/L、2.0μg/L和10.0μg/L为界分为4组。血清C-反应蛋白水平以10 mg/L与50 mg/L为界分为3组。结果:患儿的病死率随血清降钙素原水平升高而增高(P<0.05);而在C-反应蛋白的分析中,高水平的C-反应蛋白患儿与正常C-反应蛋白患儿相比,病死率无统计学差异(P>0.05)。结论:儿童危重症患儿血清降钙素原水平与患儿预后关系密切。
OBJECTIVE: To study the relationship between serum procalcitonin and C-reactive protein levels and prognosis in critically ill children, and explore their relationship with the prognosis of critically ill patients. Methods: A retrospective analysis of 108 patients admitted to the Neonatal Intensive Care Unit and Pediatric Intensive Care Unit of the First Affiliated Hospital of Harbin Medical University from January 2011 to June 2013 was conducted. According to their serum procalcitonin and C-response The measured values of protein levels were grouped separately to calculate the case fatality rate and statistically compared. Serum procalcitonin levels were divided into 4 groups by 0.5 μg / L, 2.0 μg / L and 10.0 μg / L. Serum C-reactive protein levels were divided into 3 groups by 10 mg / L and 50 mg / L. Results: The case fatality rate increased with the increase of serum procalcitonin (P <0.05). However, in the analysis of C-reactive protein, the high level of C-reactive protein in children with normal C-reactive protein There was no significant difference in mortality among children (P> 0.05). Conclusion: Serum procalcitonin levels in children with critical illness are closely related to the prognosis of children.