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从文献得知,国内某些医院将乌洛托品当作治疗病毒性脑炎的抗病毒药应用,笔者仅提出质疑如下。查乌洛托品本身并无抗菌效果,只是在溶液中分解出甲醛后,后者与蛋白氨基相结合,引起蛋白变性才能起抗菌作用。治疗病毒性脑炎的设想亦可能是让乌洛托品释出甲醛灭活病毒,但已知乌洛托品只有在pH值为5.6以下的酸性溶液中,才能分解出甲醛,甚至降至5.0或更低才行。可是,正常体液pH值在7.35～7.45,即使在严重的失代偿性酸中毒时,也只降至7.2～7.1。因此,不论在任何生理或病理情况下,乌洛托品在体液循环中都不会分解,只有在酸化了的尿中才能发挥抗菌作用。故乌洛托品对脑膜、关节、胆道等感染毫无用处;同理,对病毒性脑炎亦不可能有治疗效果。
It is known from the literature that some domestic hospitals treat the urotropine as an antiviral drug for the treatment of viral encephalitis, and the author merely asks the following questions. Check methenamine product itself does not have antibacterial effect, but after the decomposition of formaldehyde in solution, the latter combined with protein amino, causing protein denaturation in order to play an antibacterial effect. The idea of treating viral encephalitis may also be to release methenamine for formaldehyde inactivating the virus, but it is known that methenamine only decomposes formaldehyde in acidic solutions at pH 5.6 or lower to 5.0 Or lower Caixing. However, the normal body fluid pH value of 7.35 ~ 7.45, even in severe decompensated acidosis, it dropped to 7.2 to 7.1. Therefore, no matter in any physiological or pathological conditions, urotropine will not break down in the circulation of the body fluids and will exert its antibacterial effect only in acidified urine. Therefore, urotropin on the meninges, joints, biliary and other infections useless; the same token, viral encephalitis can not have a therapeutic effect.