论文部分内容阅读
目的分析湖北省2010—2015年手足口病(hand,foot and mouth disease,HFMD)的实验室病例的病原学及流行病学特征,为制定防控措施提供科学依据。方法利用中国疾病预防控制信息系统,采用描述流行病学方法对湖北省2010—2015年HFMD监测资料和病原学监测结果进行统计学分析,采用实时荧光定量聚合酶链反应(real-time polymerase chain reaction,real-time PCR)方法对HFMD病例进行肠道病毒71型(human enterovirus 71,EV71)和柯萨奇病毒A16型(coxsackie virus A16,CoxA16)核酸检测。结果湖北省2010—2015年累计报告HFMD 473 593例,年平均发病率为136.3/10万,发病率呈大小年趋势,但总体是增长趋势。发病高峰集中在4—6月,湖北省鄂西北地区发病率最高。男性发病率为高于女性。年龄组发病以散居儿童为主;病原学监测结果 EV71所占比例为75.76%,CoxA16所占比例为10.74%。结论湖北省HFMD流行有明显的人群性、季节性、地区性。引起HFMD流行的主要病原体为EV71和CoxA16。
Objective To analyze the etiological and epidemiological characteristics of laboratory cases of hand, foot and mouth disease (HFMD) in Hubei Province from 2010 to 2015, and provide a scientific basis for the development of prevention and control measures. Methods Using the information system of China’s disease prevention and control, the descriptive epidemiological method was used to analyze the monitoring data of HFMD in Hubei Province from 2010 to 2015 and the etiological surveillance results. The real-time polymerase chain reaction , real-time PCR method was used to detect the nucleic acid of human enterovirus 71 (EV71) and coxsackie virus A16 (CoxA16) in HFMD cases. Results A total of 473 593 cases of HFMD were reported from 2010-2015 in Hubei Province. The annual average incidence rate was 136.3 / 100000. The incidence rate showed an annual trend of size, but the trend was overall. The peak incidence concentrated in April-June, Hubei Province, Hubei Province, the highest incidence of Northwest. The incidence of males is higher than that of females. The onset of the age group was dominated by scattered children. The etiological surveillance results were 75.76% for EV71 and 10.74% for CoxA16. Conclusion The prevalence of HFMD in Hubei Province is obviously population, seasonal and regional. The major pathogens causing the epidemic of HFMD are EV71 and CoxA16.