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以ＨｙｐｅｒｓｉｌＯＤＳ为色谱柱、乙腈－二乙胺缓冲液（２０８０）为流动相，采用ＲＰ－ＨＰＬＣ法测定盐酸曲马朵滴剂的含量。曲马朵与其顺式异构体、辅料中抗氧剂成分能完全分离。平均回收率为１００．８５％，ＲＳＤ为０．８０％。
Hypersil ODS column and acetonitrile-diethyl amine buffer (2080) were used as the mobile phase. The contents of tramadol hydrochloride drops were determined by RP-HPLC. Tramadol and its cis-isomer, accessories antioxidant component can be completely separated. The average recovery was 100.85% with a RSD of 0.80%.